Lab Sciences
Top stories summarized by our editors
1/11/2018

A new star-shaped pill in the early stages of being developed could reduce the number of times people with HIV need to take their medications to once a week, with the pill containing "multiple drug-polymer combinations and slowly [releasing] drugs over the course of seven days," said researcher Dr. Giovanni Traverso. The study was published in the journal Nature Communications.

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HealthDay News
1/10/2018

A study in JAMA Ophthalmology found that corneal donor tissue can be safely stored for 11 days before transplantation. The findings were based on data for Descemet stripping automated endothelial keratoplasty procedures for 1,330 eyes.

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Medical Xpress
1/10/2018

Placental tissue donations can be processed for use in treating conditions such as burns, surgical wounds and diabetic ulcers, writes Sarah Gray of the American Association of Tissue Banks. Two grafts from the donation were used to promote healing after surgery for a 5-year-old boy with osteosarcoma, and parents interested in donation can begin by asking a local organ procurement organization for their recommendations or using the AATB's Accredited Bank Search, Gray writes.

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Medium
1/10/2018

Stem cell researchers at Indiana University School of Medicine cultivated skin with hair follicles from pluripotent stem cells of mice, according to a paper in the journal Cell Reports. "The skin is a complex organ that has been difficult to fully re-create and maintain in culture for research purposes," researcher and surgery professor Karl Koehler said.

1/10/2018

Cantex Pharmaceuticals' investigational agent CX-01 received orphan drug designation from the FDA as a treatment for acute myeloid leukemia. Cantex has an ongoing 75-patient midstage trial to evaluate CX-01's potential in enhancing front-line chemotherapy for AML.

1/9/2018

An Iowa woman with a nonhealing diabetic foot ulcer was treated successfully with Grafix, cryopreserved human placental tissue, at the Wound Care Center at Mercy Medical Center. The treatment "really is a game-changer for these types of injuries and these types of ulcers," said Michael Garrett, a certified hyperbaric wound specialist and advanced registered nurse practitioner at Mercy.

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diabetic foot ulcer, Grafix
1/9/2018

A trace and toxic element testing laboratory increased its capacity and improved handling of testing volume without increasing footprint with a quality control initiative that reduced troubleshooting and analytical run times per sample. Such initiatives "may provide confidence for labs that larger-scale implementation improvement initiatives will be worth the time and effort," write Valentinas Gruzdys from the University of Utah and Frederick Strathmann from NMS Labs.

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University of Utah
1/9/2018

Preliminary results from a midstage study found improvement in sickle cell disease symptoms in 83% of adolescents treated with Global Blood Therapeutics' voxelotor. The FDA has designated the drug as a breakthrough therapy, and voxelotor is believed to block polymerization and sickling of red blood cells, potentially restoring normal hemoglobin function.

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Global Blood Therapeutics
1/9/2018

A midstage study in the journal Clinical Infectious Diseases found that a regimen of fosmidomycin and piperaquine induced rapid parasite clearance in patients with malaria. The treatment is being developed to address growing resistance to artemisinin-based therapies.

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Malaria
1/9/2018

New clinical studies are to be initiated by Espero Biopharma to evaluate tecarfarin, an anti-coagulation drug, and budiodarone, an atrial fibrillation treatment. The Tecarfarin for Anticoagulation Trial is slated to launch in the second quarter of 2018, while a third midstage study for budiodarone is scheduled for this year as well.